Research Associate, Process Development – Encapsulation (RI)

Job Description
Semma Therapeutics, a biotechnology company focused on developing a stem cell-based cell therapy for Type 1 Diabetes, is seeking a Research Associate to join its growing encapsulation team. The full-time role will focus on preparing Semma’s stem cell derived islets for encapsulation into a variety of delivery modalities. The Fill-Finish RA will serve as a general cell culture specialist for the Delivery group and will be involved in development of assays and processes to enable device evaluation. The position will be located in Providence, RI.

Responsibilities:

  • Work within a small team to prepare reagents and cell and device analytics aseptically
  • Perform histological imaging and analysis of tissue slides
    • Image analysis of in vitro and in vivo tissue samples
    • Quantification, statistical analysis, and presentation of translational data related to implant performance: biomass, foreign body response, and other metrics
  • Perform assays related to in-process controls and product release for Encapsulation Research team
    • Maintenance of cells and devices in culture, including routine media exchange, imaging, harvest, and sampling
    • Evaluation and characterization of explanted devices
    • Processing for histologic analysis, sample fixation, and sample tracking
  • Maintain an organized and tidy wet lab
  • Identify and implement new analytical techniques and processes for analysis of devices
  • Maintain a lab notebook, batch records/QC forms where necessary, and contribute to written reports and presentations

Required qualifications:

  • BS in Life Sciences, Bio-Engineering, or related discipline
  • Experience in wet lab
  • Demonstrated ability to perform technical manipulations using aseptic technique
  • Ability to communicate effectively with a diverse range of scientists, physicians, engineers, regulatory specialists and business professionals
  • Demonstrated excellence in planning, executing, and analyzing experiments
  • Experience with programs such as ImageJ, Excel, GraphPad Prism and PowerPoint for data analysis and presentation
  • Adaptive and a quick learner, efficient in multi-tasking and trouble-shooting, highly organized with good record keeping, excellent inter-personal and communication skills to excel in team work environment
  • Flexibility in working schedule to accommodate weekend work
  • Authorized to legally work in US

Preferred qualifications:

  • Prior work in cell culture
  • Proficiency developing and running analytical assays to characterize cell products
  • Experience with islet cultures and associated assays
  • Experience in cell encapsulation
  • Experience in histology

Please note that applicants should have authorization to work in the United States. Semma offers competitive pay, health insurance, time-off among other benefits. Please, fill out the form below and include your resume.

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