Chemical Engineer, Encapsulation R&D (RI)

Job Description
Semma Therapeutics, a biotechnology company focused on developing a stem cell-based cell therapy for Type 1 Diabetes, is seeking a Chemical Engineer to join its growing encapsulation team. The full-time role will focus on development of materials, processes, and analytical techniques related to Semma’s cell encapsulation technology. The engineer will perform reactions to functionalize, synthesize, and purify a range of encapsulation materials, including the development of relevant characterization techniques to serve as analytical metrics. The position will be located in Providence, RI.


  • Implement chemical processing strategies for purification, surface modification, and functionalization of encapsulation materials
  • evelop and perform characterization of materials and encapsulated products including mechanical testing, electron microscopy, rheology, chemical composition, and functional assays
  • Perform formulation experiments to deliver ancillary therapeutic agents in a variety of target release profiles
  • Work within a team to design, develop, and integrate microfluidic strategies into instrumentation and hardware for use in aseptic filling and encapsulation
  • Interface with simulation group to assist in the development and validation of CFD models
  • Develop standard operating procedures that can be transferred to manufacturing and implemented under GMP to maximize safety and operational effectiveness
  • Demonstrate proficiency in designing and executing scientific research experiments
  • Maintain quality written descriptions of experiments including operational procedures and sampling techniques and provide study reports.
  • Excellent oral and written communication skills, able to write technical reports and protocols

Required qualifications:

  • MS or PhD in Biomedical, Chemical or Mechanical Engineering, Material Science, Chemistry, or related field with at least 3 years of experience
  • Experience in drug delivery, cell encapsulation, or microfluidic manipulation of cell clusters including bioreactor design
  • Demonstrated proficiency in purification, modification, biomaterial functionalization including coupling reactions
  • Proficiency in standard chemical analysis techniques including FTIR and NMR
  • Flexibility in working schedule to accommodate occasional weekend work
  • Authorized to legally work in US on a continuous basis

Preferred qualifications:

  • Experience designing processing instrumentation including scale-up
  • Experience in tech transfer to GMP
  • Proficiency in mathematical modeling including CFD and diffusion
  • Experience in microfluidics

Please note that applicants should have authorization to work in the United States. Semma offers competitive pay, health insurance, time-off among other benefits. Please, fill out the form below and include your resume.


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